Hepatic phenylalanine 4-monooxygenase is a phosphoprotein
نویسندگان
چکیده
منابع مشابه
Detection of hepatic phenylalanine 4-hydroxylase in classical phenylketonuria.
An extract from a liver biopsy of a patient with classical phenylketonuria contains phenylalanine 4-hydroxylase (EC 1.14.3.1) with a specific activity 0.27% of the normal activity of the hydroxylase. This enzyme from a patient with phenylketonuria is a structurally altered form of phenylalanine 4-hydroxylase that probably results from a mutation in the gene coding for the hydroxylase.
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Flavin-containing monooxygenases (FMOs) are one of the most important monooxygenase systems in Eukaryotes and have many important physiological functions. FMOs have also been found in bacteria; however, their physiological function is not known. Here, we report the identification and characterization of trimethylamine (TMA) monooxygenase, termed Tmm, from Methylocella silvestris, using a combin...
متن کاملHepatic metabolism of phenylalanine during development.
The phenomenon of substrate induced enzyme formation has been amply documented in studies of microbial systems (1), and similar adaptive changes in enzymic activity in the tissues of vertebrate forms have been described by Knox, Mehler and Lin (2, 3) and by others (4, 5). The suggestion has been made (4, 6) that substrate induction may be a mechanism involved in those changes in enzymatic activ...
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Phenylalanine hydroxylase was shown to be inhibited by oudenone and its derivatives in vitro. At a concentration of 2.3 x 10(-3) M, oudenone inhibited phenylalanine hydroxylase by 50%, and some of the oudenone derivatives showed more potent inhibition. The kinetic data have shown that the inhibition by oudenone is competitive with a tetrahydropterin cofactor (6,7-dimethyltetrahydropterin, DMPH4...
متن کاملOxygen reaction of 4-hydroxybenzoate monooxygenase.
Among monooxygenases the flavin containing enzymes were the first being purified and crystallized since they consist of only one single protein in contrast to the multienzyme structure of the metal containing monooxygenases. Flavin plays a dual role in these enzymes acting as electron acceptor and oxygen activating site simultaneously. Kinetic measurements by NAKAMURA et al.1 on the 4-hydroxybe...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1976
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.73.5.1591